- Evaluation of systemic administration of Boswellia papyrifera extracts on
spatial memory retention in male rats Author(s): Mahmoudi A,
Hosseini-Sharifabad A, Monsef-Esfahani HR, et al. Source: JOURNAL OF NATURAL
MEDICINES Volume: 65 Issue: 3-4 Pages: 519-525 Published: JUL 2011
- Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP)
through phosphorylation at Ser(87) to suppress apoptotic cell death Author(s):
Kato Kiyoko; Tanaka Toshihisa; Sadik Golam; et al. Source: PSYCHOGERIATRICS
Volume: 11 Issue: 2 Pages: 90-97 DOI: 10.1111/j.1479-8301.2011.00355.x
Published: JUN 2011
- PKC epsilon Activation Prevents Synaptic Loss, A beta Elevation, and
Cognitive Deficits in Alzheimer's Disease Transgenic Mice Author(s):
Hongpaisan J, Sun MK, Alkon DL Source: JOURNAL OF NEUROSCIENCE Volume: 31
Issue: 2 Pages: 630-643 Published: JAN 12 2011
- Natural products as a source of Alzheimer's drug leads Author(s): Williams
P, Sorribas A, Howes MJR Source: NATURAL PRODUCT REPORTS Volume: 28 Issue: 1
Pages: 48-77 Published: 2011
- Identification of Novel Small Molecule Activators of Nuclear Factor-kappa
B With Neuroprotective Action Via High-Throughput Screening Author(s):
Manuvakhova MS, Johnson GG, White MC, et al. Source: JOURNAL OF NEUROSCIENCE
RESEARCH Volume: 89 Issue: 1 Pages: 58-72 Published: JAN 2011
- Pharmacology of protein kinase C activators: Cognition-enhancing and
antidementic therapeutics Author(s): Sun MK, Alkon DL Source: PHARMACOLOGY &
THERAPEUTICS Volume: 127 Issue: 1 Pages: 66-77 Published: JUL 2010
- Calcium Induces Expression of Cytoplasmic Gelsolin in SH-SY5Y and HEK-293
Cells Author(s): Ji LN, Chauhan A, Chauhan V Source: NEUROCHEMICAL RESEARCH
Volume: 35 Issue: 7 Pages: 1075-1082 Published: JUL 2010
- Early diagnostic accuracy and pathophysiologic relevance of an
autopsy-confirmed Alzheimer's disease peripheral biomarker Author(s): Khan TK,
Alkon DL Source: NEUROBIOLOGY OF AGING Volume: 31 Issue: 6 Pages: 889-900
Published: JUN 2010
- Upregulation of Cytoplasmic Gelsolin, an Amyloid-beta-Binding Protein,
Under Oxidative Stress Conditions: Involvement of Protein Kinase C Author(s):
Ji LN, Chauhan A, Chauhan V Source: JOURNAL OF ALZHEIMERS DISEASE Volume: 19
Issue: 3 Pages: 829-838 Published: 2010
- Protein kinase C as a peripheral biomarker for Alzheimer's disease
Author(s): de Barry J, Liegeois CM, Janoshazi A Source: EXPERIMENTAL
GERONTOLOGY Volume: 45 Issue: 1 Special Issue: Sp. Iss. SI Pages: 64-69
Published: JAN 2010
- Protein Kinase C Activators as Synaptogenic and Memory Therapeutics
Author(s): Sun MK, Alkon DL Source: ARCHIV DER PHARMAZIE Volume: 342 Issue: 12
Pages: 689-698 Published: DEC 2009
- Protein Kinase C Involvement in the Acetylcholine Release Reduction
Induced by Amyloid-beta(25-35) Aggregates on Neuromuscular Synapses Author(s):
Tomas M, Garcia N, Santafe MM, et al. Source: JOURNAL OF ALZHEIMERS DISEASE
Volume: 18 Issue: 4 Pages: 877-884
- A cellular model of Alzheimer's disease therapeutic efficacy: PKC
activation reverses A beta-induced biomarker abnormality on cultured
fibroblasts Author(s): Khan TK, Nelson TJ, Verma VA, et al. Source:
NEUROBIOLOGY OF DISEASE Volume: 34 Issue: 2 Pages: 332-339 Published: MAY 2009
- Protein kinase C mediates amyloid beta-protein fragment 31-35-induced
suppression of hippocampal late-phase long-term potentiation in vivo Author(s):
Zhang JF, Qi JS, Qiao JT Source: NEUROBIOLOGY OF LEARNING AND MEMORY Volume:
91 Issue: 3 Pages: 226-234 Published: MAR 2009
- Insulin, PKC signaling pathways and synaptic remodeling during memory
storage and neuronal repair Author(s): Nelson TJ, Sun MK, Hongpaisan J, et al.
Source: EUROPEAN JOURNAL OF PHARMACOLOGY Volume: 585 Issue: 1 Pages: 76-87
Published: MAY 6 2008
- Synergistic effects of chronic bryostatin-1 and alpha-tocopherol on
spatial learning and memory in rats Author(s): Sun MK, Alkon DL Source:
EUROPEAN JOURNAL OF PHARMACOLOGY Volume: 584 Issue: 2-3 Pages: 328-337
Published: APR 28 2008
- Nelson TJ, Alkon DL Protection against beta-amyloid-induced apoptosis by
peptides interacting with beta-amyloid JOURNAL OF BIOLOGICAL CHEMISTRY 282
(43): 31238-31249 OCT 26 2007
- Alkon DL, Sun MK, Nelson TJ PKC signaling deficits: a mechanistic
hypothesis for the origins of Alzheimer's disease TRENDS IN PHARMACOLOGICAL
SCIENCES 28 (2): 51-60 FEB 2007
- Khan TK, Alkon DL An internally controlled peripheral biomarker for
Alzheimer's disease: Erk1 and Erk2 responses to the inflammatory signal
bradykinin PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED
STATES OF AMERICA 103 (35): 13203-13207 AUG 29 2006
- Sun MK, Alkon DL Bryostatin-1: Pharmacology and therapeutic potential as a
CNS drug CNS DRUG REVIEWS 12 (1): 1-8 SPR 2006
- Kuzirian AM, Epstein HT, Gagliardi CJ, et al. Bryostatin enhancement of
memory in Hermissenda BIOLOGICAL BULLETIN 210 (3): 201-214 JUN 2006
- Murphy EJ, Huang HM, Cowburn RF, et al. Phospholipid mass is increased in
fibroblasts bearing the Swedish amyloid precursor mutation BRAIN RESEARCH
BULLETIN 69 (1): 79-85 MAR 15 2006
- Li X, Lu F, Tian Q, et al. Activation of glycogen synthase kinase-3
induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in
culture J NEURAL TRANSM 113 (1): 93-102 JAN 2006
- Misiti F, Sampaolese B, Pezzotti M, et al. A beta(31-35) peptide induce
apoptosis in PC 12 cells: Contrast with A beta(25-35) peptide and examination
of underlying mechanisms NEUROCHEM INT 46 (7): 575-583 JUN 2005
- Sun MK, Alkon DL Dual effects of bryostatin-1 on spatial memory and
depression EUR J PHARMACOL 512 (1): 43-51 APR 4 2005
- Morgan C, Colombres M, Nunez MT, et al. Structure and function of amyloid
in Alzheimer's disease PROG NEUROBIOL 74 (6): 323-349 DEC 2004
- Sun MK, Alkon DL Cerebral hypoperfusion and amyloid-induced synergistic
impairment of hippocampal CA1 synaptic efficacy and spatial memory in young
adult rats J ALZHEIMERS DIS 6 (4): 355-366 AUG 2004
- Etcheberrigaray R, Tan M, Dewachter I, et al. Therapeutic effects of PKC
activators in Alzheimer's disease transgenic mice P NATL ACAD SCI USA 101
(30): 11141-11146 JUL 27 2004
- Lee W, Boo JH, Jung MW, et al. Amyloid beta peptide directly inhibits PKC
activation MOL CELL NEUROSCI 26 (2): 222-231 JUN 2004
- Sponne I, Fifre A, Kriem B, et al. Membrane cholesterol interferes with
neuronal apoptosis induced by soluble oligomers but not fibrils of the amyloid-beta
peptide FASEB J 18 (3): - MAR 2004
- Singh AB, Harris RC Epidermal growth factor receptor activation
differentially regulates claudin expression and enhances transepithelial
resistance in Madin-Darby canine kidney cells J BIOL CHEM 279 (5): 3543-3552
JAN 30 2004
- Matsumoto S, Shamloo M, Matsumoto E, et al. Protein kinase C-gamma and
calcium/calmodulin-dependent protein kinase II-alpha are persistently
translocated to cell membranes of the rat brain during and after middle
cerebral artery occlusion J CEREBR BLOOD F MET 24 (1): 54-61 JAN 2004
- Liu SJ, Zhang AH, Li HL, et al. Overactivation of glycogen synthase
kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads
to hyperphosphorylation of tau and impairment of spatial memory J NEUROCHEM 87
(6): 1333-1344 DEC 2003
- Cedazo-Minguez A, Popescu BO, Blanco-Millan JM, et al. Apolipoprotein E
and beta-amyloid (1-42) regulation of glycogen synthase kinase-3 beta J
NEUROCHEM 87 (5): 1152-1164 DEC 2003
- Jong YJI, Ford SR, Seehra K, et al. Alzheimer's disease skin fibroblasts
selectively express a bradykinin signaling pathway mediating tau protein Ser
phosphorylation FASEB J 17 (13): U421-+ OCT 2003
- De Ferrari GV, Chacon MA, Barria MI, et al. Activation of Wnt signaling
and behavioral impairments rescues neurodegeneration induced by beta-amyloid
fibrils MOL PSYCHIATR 8 (2): 195-208 2003
- De Ferrari GV, Chacon MA, Barria MI, et al. Activation of Wnt signaling
and behavioral impairments rescues neurodegeneration induced by beta-amyloid
fibrils MOL PSYCHIATR 8 (2): 195-208 2003
- Sponne I, Fifre A, Drouet A, et al. Apoptotic neuronal cell death induced
by the non-fibrillar amyloid-beta peptide proceeds through an early reactive
oxygen species-dependent cytoskeleton perturbation J BIOL CHEM 278 (5):
3437-3445 JAN 31 2003
- Olariu A, Yamada K, Mamiya T, et al. Memory impairment induced by chronic
intracerebroventricular infusion of beta-amyloid (1-40) involves
downregulation of protein kinase C BRAIN RES 957 (2): 278-286 DEC 13 2002
- Zhao WQ, Ravindranath L, Mohamed AS, et al. MAP kinase signaling cascade
dysfunction specific to Alzheimer's disease in fibroblasts NEUROBIOL DIS 11
(1): 166-183 OCT 2002
- Garrido JL, Godoy J, Alvarez A, et al.Protein kinase C inhibits amyloid
beta-peptide neurotoxicity by acting on members of the Wnt pathway FASEB J 16
(12): U8-U27 OCT 2002
- Pakaski M, Balaspiri L, Checler F, et al. Human amyloid-beta causes
changes in the levels of endothelial protein kinase C and its alpha isoform in
vitro NEUROCHEM INT 41 (6): 409-414 DEC 2002
- Inestrosa NC, De Ferrari GV, Garrido JL, et al. Wnt signaling involvement
in beta-amyloid-dependent neurodegeneration NEUROCHEM INT 41 (5): 341-344 NOV
2002
- Sun MK, Alkon DL Impairment of hippocampal CA1 heterosynaptic
transformation and spatial memory by beta-amyloid(25-35) J NEUROPHYSIOL 87
(5): 2441-2449 MAY 2002
- Cedazo-Minguez A, Wiehager B, Winblad B, et al. Effects of apolipoprotein E (apoE)
isoforms, beta-amyloid (A beta) and apoE/A beta complexes on protein kinase C-alpha
(PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y
neuroblastoma cells and fibroblasts
NEUROCHEM INT 38: (7) 615-625 JUN 2001
- Rossner
S, Mehlhorn G, Schliebs R, et al. Increased neuronal and glial expression of protein
kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology EUR J
NEUROSCI 13: (2) 269-278 JAN 2001
- Kuperstein F, Reiss N, Koudinova N, et al. Biphasic modulation of protein kinase C and
enhanced cell toxicity by amyloid beta peptide and anoxia in neuronal cultures J NEUROCHEM
76: (3) 758-767 FEB 2001
- Fukushima S, Kishimoto S, Takeuchi Y, et al. Preparation and evaluation of o/w type
emulsions containing antitumor prostaglandin ADV DRUG DELIVER REV 45: (1) 65-75 DEC 6 2000
- Tremblay R, Chakravarthy B, Hewitt K, et al. Transient NMDA receptor inactivation
provides long-term protection to cultured cortical neurons from a variety of death signals
J NEUROSCI 20: (19) 7183-7192 OCT 1 2000
- De Ferrari GV, Inestrosa NC Wnt signaling function in Alzheimer's disease BRAIN RES REV
33: (1) 1-12 AUG 2000
- Favit A, Grimaldi M, Alkon DL Prevention of beta-amyloid neurotoxicity by blockade of
the ubiquitin-proteasome proteolytic pathway J NEUROCHEM 75: (3) 1258-1263 SEP 2000
- Murphy EJ, Zhang H, Sorbi S, et al. Phospholipid composition and levels are not altered
in fibroblasts bearing presenilin-1 mutations BRAIN RES BULL 52: (3) 207-212 JUN 2000
- Christner C, Wyrwa R, Marsch S, et al Synthesis
and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBDP12
with neuroregenerative properties J MED CHEM 42: (18) 3615-3622 SEP 9 1999
- Pillot T, Drouet B, Queille S, et al. The nonfibrillar amyloid beta-peptide induces
apoptotic neuronal cell death: Involvement of its C-terminal fusogenic domain J NEUROCHEM
73: (4) 1626-1634 OCT 1999
- Ibarreta D, Duchen M, Ma DW, et al. Benzolactam (BL) enhances sAPP secretion in
fibroblasts and in PC12 cells
NEUROREPORT 10: (5) 1035-1040 APR 6 1999